PMID

Data

Article Title

Organization

De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization.

The Walter and Eliza Hall Institute of Medical Research

Fluorescent ligands for adenosine receptors.

National Institute of Diabetes and Digestive and Kidney Diseases

Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.

National Institute of Diabetes and Digestive and Kidney Diseases

QSAR study on a novel series of 8-azaadenine analogues proposed as A1 adenosine receptor antagonists.

University of Pisa

2-aralkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.

University of South Florida

Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.

National Institute of Diabetes and Digestive and Kidney Diseases

2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.

University of Bonn

Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.

National Institute of Diabetes and Digestive and Kidney Diseases

5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species.

Universit£

Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.

Universit£

1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies.

Universit£

Synthesis, molecular modeling studies, and pharmacological activity of selective A(1) receptor antagonists.

Universit£

3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.

Universit£

A novel class of highly potent and selective A1 adenosine antagonists: structure-affinity profile of a series of 1,8-naphthyridine derivatives.

Universit£

2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.

Universit£

Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine.

Kyowa Hakko Kogyo

Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.

Kyowa Hakko Kogyo

8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.

Kyowa Hakko Kogyo

Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.

Niddk

2-(N'-aralkylidenehydrazino)adenosines: potent and selective coronary vasodilators.

University of South Florida

Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists.

National Institute of Diabetes

Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.

Kyowa Hakko Kogyo

2-Alkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.

University of South Florida

1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists.

Center For Bio-Pharmaceutical Sciences

Electrophilic derivatives of purines as irreversible inhibitors of A1 adenosine receptors.

Niddk

125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors.

University of Virginia School of Medicine

Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application.

TBA

Adenosine receptors: targets for future drugs.

TBA

Structure-affinity relationships of 5'-aromatic ethers and 5'-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents.

Cv Therapeutics

The discovery and synthesis of highly potent, A2a receptor agonists.

Glaxowellcome Medicines Research Centre

The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists.

Universita` Degli Studi Di Firenze

Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands.

Dipartimento Di Scienze Farmaceutiche

 

Synthesis of 5-(3-Hydroxypropyl)-7-methoxy-2-(3‘-methoxy-4‘-hydroxyphenyl)-3- benzo[b]furancarbaldehyde, a Novel Adenosine A₁ Receptor Ligand from the Root of Salvia miltiorrhiza

TBA

 

Adenosine A_2A antagonists with potent anti-cataleptic activity

TBA

 

Discovery of FK453, a novel non-xanthine adenosine A₁ receptor antagonist

TBA

Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.

Universita Di Firenze

Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.

Universita' Di Firenze

Synthesis, biological activity and molecular modelling of new trisubstituted 8-azaadenines with high affinity for A1 adenosine receptors.

Università

Expanding the repertoire of methanocarba nucleosides from purinergic signaling to diverse targets.

National Institute of Diabetes & Digestive & Kidney Diseases

4-amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. synthesis, pharmacological evaluation, and ligand-receptor modeling studies.

Università

A

National Institute of Diabetes and Digestive and Kidney Disease

1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation, and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives.

Università

Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors.

Università

1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors.

Dipartimento Di Scienze Farmaceutiche

Selective A

National Institute of Diabetes and Digestive and Kidney Diseases

Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives.

Università

Direct Comparison of (N)-Methanocarba and Ribose-Containing 2-Arylalkynyladenosine Derivatives as A

National Institute of Diabetes and Digestive and Kidney Disease

Synthesis and evaluation of no-carrier-added 8-cyclopentyl-3-(3-[(18)F]fluoropropyl)-1-propylxanthine ([(18)F]CPFPX): a potent and selective A(1)-adenosine receptor antagonist for in vivo imaging.

Forschungszentrum JüLich

Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists.

Università

Opportunities for Tapping into Three-Dimensional Chemical Space through a Quaternary Carbon.

St. John'S University

Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands.

Facoltà

Synthesis and structure-activity relationships of a new set of 2-arylpyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.

Universita' Di Firenze

Novel non-xanthine antagonist of the A

Bayer Pharmaceuticals

1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists.

Universita' Di Firenze

Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human A

Medical College of Wisconsin

Design and in Vivo Characterization of A

Medical College of Wisconsin

A

Rheinische Friedrich-Wilhelms-Universitat Bonn

Novel 3-aralkyl-7-(amino-substituted)-1,2,3-triazolo[4,5-d]pyrimidines with high affinity toward A1 adenosine receptors.

Università

A1 adenosine receptor antagonists as ligands for positron emission tomography (PET) and single-photon emission tomography (SPET).

Forschungszentrum JüLich

Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.

Cv Therapeutics

The Medicinal Chemistry of Caffeine.

Goethe-University Frankfurt

Synthesis and cardiotonic activity of novel pyrimidine derivatives: crystallographic and quantum chemical studies.

Università

Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position.

Hokuriku University

8-Azaxanthine derivatives as antagonists of adenosine receptors.

Università

Neurotransmitter receptor binding and drug discovery.

TBA

Imidazo[1,2-?]pyridines possess adenosine A

North-West University

8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.

Kyowa Hakko Kogyo

(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.

Kyowa Hakko Kogyo

2-(N'-alkylidenehydrazino)adenosines: potent and selective coronary vasodilators.

University of South Florida

7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist.

Kyowa Hakko Kogyo

Effects of alkyl substitutions of xanthine skeleton on bronchodilation.

Hokuriku University

Synthesis and in vivo evaluation of a novel 5-HT1A receptor agonist radioligand [O-methyl- 11C]2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)dione in nonhuman primates.

Columbia University

In vitro and in vivo pharmacological characterization of N6-cyclopentyl-9-methyladenine (N-0840): a selective, orally active A1 adenosine receptor antagonist.

Whitby Research

Xanthine derivatives as antagonists at A1 and A2 adenosine receptors.

TBA

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX)--a selective high affinity antagonist radioligand for A1 adenosine receptors.

UniversitÄT Heidelberg

Comparison of A1 adenosine receptors in brain from different species by radioligand binding and photoaffinity labelling.

UniversitÄT Heidelberg

Receptor binding profiles of amiloride analogues provide no evidence for a link between receptors and the Na+/H+ exchanger, but indicate a common structure on receptor proteins.

Center For Bio-Pharmaceutical Sciences